Sam is also well known in the advertising world, having scored spots for brands such as Nike, Adidas, Levi’s, ESPN, Virgin Mobile, eBay, Toyota, Jose Cuervo, Saturn, Wendy’s, and Honda while working with acclaimed directors Mark Romanek, Michel Gondry, Tarsem Singh, Lance Acord, the Malloy Brothers and Spike Jonze. The most noteworthy of all is the Jonze helmed Adidas spot entitled “Hello Tomorrow” which featured Sam’s collaboration with Karen O of the Yeah Yeah Yeahs. Written and produced by Squeak E. Clean, “Hello Tomorrow” won the Gold Lion for Best Music at the 2005 Cannes International Advertising Festival and Silver for Original Music at the 2006 Clio Awards. Sam’s most recent commercial work of note involved remixing Santigold for Mark Romanek’s Ford Flex campaign. 

While Spiegel has produced and remixed tracks for Maroon 5, Iggy Pop, Kylie Minogue, The Eels, Ben Lee, The Cardigans, Spankrock and more, 2006 saw the release of the first major label album fully produced by Squeak E. Clean. Show Your Bones, the Yeah Yeah Yeahs sophomore record, was named “Album of the Year” by the likes of Rolling Stone, NME, and Spin, and was nominated for a Grammy for best alternative album. 2009 saw Sam honing his focus on completing his longtime N.A.S.A. project (North America South America). The album, released February 2009 by ANTI- Records, is a Brazilian-inspired hip hop collaboration with longtime collaborator DJ Zegon featuring the likes of Kanye West, KRS-One, Karen O, Del the Funkee Homosapien, David Byrne, Fatlip, Tom Waits, RZA, Chali 2na, M.I.A., Spank Rock, De La Soul, Method Man, and the last recorded track from the late Ol’ Dirty Bastard, to name a few.